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By analyzing the aortic tissue, we found that FOXO4-DRI treatment significantly increased the expression levels of Ki-67 and Lamin B, while reducing the expression of P21, P16, and -H2AX, similar to the results obtained from naturally aged mice (Figure 2A)

Macrophage polarization from M1 to M2 Macrophages exist on a spectrum

Mary Claire Haver citing Mayo Clinic research

Studies have shown that increased TrxR enhances oncogenic processes in a number of ways, including enhancing tumor formation, inducing angiogenesis, and increasing resistance to cancer therapies (187)

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